查到“Inhibition of SARS-CoV 3C-like Protease Activity by Theaflavin-3,3′-digallate (TF3)”论文阐述了红茶和普洱茶可以抑制冠状病毒，发表在NCBI-PMC上，因为方法简单可行，希望可供医疗工作者借鉴参考。      

Inhibition of SARS-CoV 3C-like Protease Activity by Theaflavin-3,3′-digallate (TF3)

Chia-Nan Chen,1,* Coney P. C. Lin,1,* Kuo-Kuei Huang,1 Wei-Cheng Chen,1 Hsin-Pang Hsieh,1 Po-Huang Liang,2 and John T.-A. Hsu1,3,†

Evid Based Complement Alternat Med. 2005 Jun; 2(2): 209–215.

Published online 2005 Apr 7. doi: 10.1093/ecam/neh081

PMCID: PMC1142193

PMID: 15937562

Abstract：

SARS-CoV is the causative agent of severe acute respiratory syndrome (SARS). The virally encoded 3C-like protease (3CLPro) has been presumed critical for the viral replication of SARS-CoV in infected host cells. In this study, we screened a natural product library consisting of 720 compounds for inhibitory activity against 3CLPro. Two compounds in the library were found to be inhibitive: tannic acid (IC50 = 3 µM) and 3-isotheaflavin-3-gallate (TF2B) (IC50 = 7 µM). These two compounds belong to a group of natural polyphenols found in tea. We further investigated the 3CLPro-inhibitory activity of extracts from several different types of teas, including green tea, oolong tea, Puer tea and black tea. Our results indicated that extracts from Puer and black tea were more potent than that from green or oolong teas in their inhibitory activities against 3CLPro. Several other known compositions in teas were also evaluated for their activities in inhibiting 3CLPro. We found that caffeine, (—)-epigallocatechin gallte (EGCg), epicatechin (EC), theophylline (TP), catechin (C), epicatechin gallate (ECg) and epigallocatechin (EGC) did not inhibit 3CLPro activity. Only theaflavin-3,3′-digallate (TF3) was found to be a 3CLPro inhibitor. This study has resulted in the identification of new compounds that are effective 3CLPro inhibitors.

摘要：

SARS- cov是SARS的病原体。病毒编码的3c样蛋白酶(3CLPro)被认为是病毒复制SARS-CoV的关键。在这项研究中，我们筛选了720个化合物组成的天然产物库来抑制3CLPro的活性。两种化合物在图书馆被发现是禁止的：鞣酸(IC50 = 3µM)和3-isotheaflavin-3-gallate (TF2B) (IC50 = 7µM)。这两种化合物属于在茶中发现的一组天然多酚。我们进一步研究了绿茶、乌龙茶、普洱茶和红茶等几种不同茶提取物的抑菌活性。结果表明，普洱茶和红茶提取物对3CLPro的抑制作用强于绿茶和乌龙茶提取物。我们还评估了茶中其他几种已知成分抑制3CLPro的活性。我们发现，咖啡因，(-)儿茶素gallte (EGCg)表儿茶素(EC)，茶碱(TP)，儿茶素(C)，表儿茶素没食子酸盐(ECg)和儿茶素(EGC)没有抑制3 clpro活动。只有茶黄素-3,3 ' -二酸盐(TF3)被发现是一种3CLPro抑制剂。这项研究发现了新的化合物，是有效的3CLPro抑制剂。

来源：      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1142193/#__ffn_sectitle

      冠状病毒现在已发现有七种，最新的2019-nCoV，中东呼吸综合症MERS-CoV和非典SARS-CoV的病毒编码的3C样蛋白（3CLPro），被确定为有吸引力的药物靶标，对在受感染宿主细胞中的病毒复制至关重要。靶向冠状病毒蛋白酶3CLpro的药物就是HIV病毒蛋白酶抑制剂诺匹那韦Lopinavir，克力芝的主要成分。

    日常饮料的红茶和普洱茶所含的茶黃（TF3），根据实验发现也能夠通过抑制（3CLPro）阻止冠狀病毒的複製。

    红茶和普洱因为浓度太低不能够成为治疗药品，但所有病毒侵入人体都是由少变多，不断地复制繁殖，最后病毒发展到一定数量而发病的。

     故此，假设即使医疗人员及通过呼吸道已经被感染的初期，红茶和普洱茶漱口或者饮用，应该有防治的效果的。

    该个方法简单易行，希望大家参考。 

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